In Histamine intolerance there is an imbalance between histamine release (so-called endogenous histamine) or absorption and histamine breakdown. In most cases, the degrading enzyme DAO (diamine oxidase) is not sufficiently present or is "busy" in other ways, as it degrades other biogenic amines as well as histamine. Histamine also degrades other biogenic amines.
One strategy to improve histamine degradation is the intake of DAO and HNMT coenzymes - vitamin B6 and glutathione are often mentioned by scientists. Coenzymes ensure optimal function of these enzymes.
However, vitamin B6 can do more than that: a sufficiently high supply of vitamin B6 helps to ensure that our cells do not react so strongly to steroid hormones (such as cortisol), as it alters the transcription (reading of genetic code) of the receptor.
Since Vitamin B6 is also needed in amino acid metabolism and fat metabolism, a sufficient supply of vitamin B6 should be ensured, especially with a high-protein diet.
Zinc helps to reduce itching and plays an important role in the regulation of the immune system, as it regulates the so-called cytokines (i.e. your inflammatory messengers) and thus also the histamine release.
Vitamin C can also reduce the release of histamine from mast cells. The vitamin C metabolism has some special features that we would like to briefly explain here: first of all, vitamin C is absorbed in a dose-dependent manner, i.e. after a certain threshold dose (usually 200 mg) you can no longer absorb 100% of the active substance. A higher initial level should ensure that the absorbed vitamin C not only reaches the liver, but that enough remains for all other tissues.
The vitamin C is excreted by the kidneys during the day. This means that there would be nothing left at night. For a lasting supply of vitamin C, it makes sense to spread the intake of our capsules over the course of the day - for example, take one in the morning and one in the evening.
Glutathione is an important tripeptide that occurs in particularly high concentrations in our liver and is involved in many detoxification reactions. It renders hydrogen peroxide and free oxygen radicals harmless and participates in the regulation of the immune system.
As a peptide, however, it is already broken down into its components glycine, cysteine and glutamic acid in the intestine. So what is the point? Also in the intestinal lumen (i.e. exactly where the active ingredient goes with the capsule) many redox reactions take place for which glutathione is needed. Et voilà - we deliver it directly there.
Do not exceed the recommended daily intake. Food supplements are not a substitute for a balanced and varied diet.
Keep out of reach of children.
Store in a dry, cool place away from light. Keep away from heat and direct sunlight.
Packed in a light-protected PETPacker can - free of BPA.
What else can I do with a (suspected) histamine intolerance?
Most guidelines and the latest review by Hrubisko et al. (Nutrients 2021) recommend good medical monitoring to clearly establish the diagnosis (after all, other diseases such as intestinal inflammation can also cause similar symptoms) and to evaluate an accompanying drug therapy or nutritional therapy (e.g. low histamine diet) for you.
To help you find out which foods contain how much histamine, here is a link for you:
Histamine nutrition guide
|Ingredients per daily dose (2 capsules)
|L-ascorbic acid (99% vitamin C)
|Pyridoxine HCl (82.3%)
|| 1.8mg (1.5 mg vitamin B6)
|Zinc citrate (31.1%)
||40 mg (12.5 mg zinc)
*Percentage of the nutrient reference quantity according to Regulation (EU) No. 1169/2011
**no reference available
Capsule shell: hydroxpropylmethylcellulose, guaranteed free of PEG and carrageenan
Filler: Cellulose powder
Allergens: none contained
Capsule weight: 845.3 mg
Net weight per can (60 capsules): 50.7g
Recommended intake / dosage
Take 1 capsule with 200 ml water twice daily.
For a lasting effect, we recommend taking it over a period of about 4 weeks.
High doses of vitamin C may cause nausea, flatulence and diarrhoea. When taking blood-thinning medication, the blood coagulation status should be monitored in case of high therapeutic vitamin C doses. If there is an increased risk of kidney stones, high vitamin C doses should be avoided (according to experts from 2-3g/day). People with a disorder of iron metabolism (haemochromatosis) should only take vitamin C after consulting their doctor or pharmacist.
High doses of zinc can reduce intestinal copper absorption.
As there are no studies on use during pregnancy, breastfeeding or in children, we recommend taking it in these cases only after consulting a doctor.
Our quality promise
Our capsules are made of HPMC (hydroxypropylmethylcellulose) - i.e. vegetable cellulose and do not contain any potentially harmful substances such as PEG (polyethylene glycol) or carrageenan.
All ingredients are tested in an HACCP- and GMP-certified plant in Austria according to the quality standards valid in the EU and are also encapsulated here.
We do not use any potentially harmful release agents or superplasticisers such as titanium dioxide or silicon dioxide; if necessary, we use microcrystalline cellulose as a filler.
All our products are GMO-free, gluten-free and lactose-free. All products are also suitable for a vegan diet.
For all those who would like to know more:
Here you will find selected studies that have investigated a potential benefit of the substances used or simply explain the topic of histamine intolerance and stress in more detail:
Hrubisko M, Danis R, Huorka M, Wawruch M. Histamine Intolerance-The More We Know the Less We Know. A Review. Nutrients. 2021;13(7):2228. published 2021 Jun 29. doi:10.3390/nu13072228.
Tully DB, Allgood VE, Cidlowski JA. Modulation of steroid receptor-mediated gene expression by vitamin B6. FASEB J. 1994 Mar 1;8(3):343-9. PMID: 8143940.
Jarisch R, Weyer D, Ehlert E, Koch CH, Pinkowski E, Jung P, Kähler W, Girgensohn R, Kowalski J, Weisser B, Koch A. Impact of oral vitamin C on histamine levels and seasickness. J Vestib Res. 2014;24(4):281-8. doi: 10.3233/VES-140509. PMID: 25095772.
Johnston CS, Solomon RE, Corte C. Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults. J Am Coll Nutr. 1996 Dec;15(6):586-91. doi: 10.1080/07315724.1996.10718634. PMID: 8951736.
Hirota K, Sato T, Hashimoto Y, Yoshioka H, Ohtomo N, Ishihara H, Matsuki A. Relaxant effect of magnesium and zinc on histamine-induced bronchoconstriction in dogs. Crit Care Med. 1999 Jun;27(6):1159-63. doi: 10.1097/00003246-199906000-00042. PMID: 10397222.
Huszti Z, Horváth-Sziklai A, Noszál B, Madarász E, Deli AM. Enhancing effect of zinc on astroglial and cerebral endothelial histamine uptake. Biochem Pharmacol. 2001 Dec 1;62(11):1491-500. doi: 10.1016/s0006-2952(01)00781-x. PMID: 11728385.
Harisch G, Kretschmer M. Some aspects of a non-linear effect of zinc ions on the histamine release from rat peritoneal mast cells. Res Commun Chem Pathol Pharmacol. 1987 Jan;55(1):39-48. PMID: 2436270.
Sanada S, Kuze M, Yoshida O. [Beneficial effect of zinc supplementation on pruritus in hemodialysis patients with special reference to changes in serum histamine levels]. Hinyokika Kiyo. 1987 Dec;33(12):1955-60. Japanese. PMID: 3448919.
Marone G, Findlay SR, Lichtenstein LM. Modulation of histamine release from human basophils in vitro by physiological concentrations of zinc. J Pharmacol Exp Ther. 1981 May;217(2):292-8. PMID: 6164779.