For all those who would like to know more:

Here you will find selected studies that have investigated a potential benefit of the substances used or simply explain the topic of histamine intolerance and stress in more detail:

Histamine intolerance:

Hrubisko M, Danis R, Huorka M, Wawruch M. Histamine Intolerance-The More We Know the Less We Know. A Review. Nutrients. 2021;13(7):2228. published 2021 Jun 29. doi:10.3390/nu13072228.

Vitamin B6:

Tully DB, Allgood VE, Cidlowski JA. Modulation of steroid receptor-mediated gene expression by vitamin B6. FASEB J. 1994 Mar 1;8(3):343-9. PMID: 8143940.

Vitamin C:

Jarisch R, Weyer D, Ehlert E, Koch CH, Pinkowski E, Jung P, Kähler W, Girgensohn R, Kowalski J, Weisser B, Koch A. Impact of oral vitamin C on histamine levels and seasickness. J Vestib Res. 2014;24(4):281-8. doi: 10.3233/VES-140509. PMID: 25095772.

Johnston CS, Solomon RE, Corte C. Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults. J Am Coll Nutr. 1996 Dec;15(6):586-91. doi: 10.1080/07315724.1996.10718634. PMID: 8951736.


Hirota K, Sato T, Hashimoto Y, Yoshioka H, Ohtomo N, Ishihara H, Matsuki A. Relaxant effect of magnesium and zinc on histamine-induced bronchoconstriction in dogs. Crit Care Med. 1999 Jun;27(6):1159-63. doi: 10.1097/00003246-199906000-00042. PMID: 10397222.

Huszti Z, Horváth-Sziklai A, Noszál B, Madarász E, Deli AM. Enhancing effect of zinc on astroglial and cerebral endothelial histamine uptake. Biochem Pharmacol. 2001 Dec 1;62(11):1491-500. doi: 10.1016/s0006-2952(01)00781-x. PMID: 11728385.

Harisch G, Kretschmer M. Some aspects of a non-linear effect of zinc ions on the histamine release from rat peritoneal mast cells. Res Commun Chem Pathol Pharmacol. 1987 Jan;55(1):39-48. PMID: 2436270.

Sanada S, Kuze M, Yoshida O. [Beneficial effect of zinc supplementation on pruritus in hemodialysis patients with special reference to changes in serum histamine levels]. Hinyokika Kiyo. 1987 Dec;33(12):1955-60. Japanese. PMID: 3448919.

Marone G, Findlay SR, Lichtenstein LM. Modulation of histamine release from human basophils in vitro by physiological concentrations of zinc. J Pharmacol Exp Ther. 1981 May;217(2):292-8. PMID: 6164779.