What we have thought about
Nature offers us potent substances - for example, polyphenols. A polyphenol-rich diet (e.g. walnuts, green tea, green vegetables, blueberries, etc.) can also have a positive effect on our metabolism and immune system.
A subgroup of polyphenols are the so-called flavonoids, which are yellow plant pigments produced by the plant to protect it or its flowers and leaves from harmful influences.
Our preparation combines 4 different flavonoids to achieve optimal effect: quercetin, rutin, luteolin and genistein.
The whole is supplemented by PEA (palmitoylethanolamide). This is a fatty acid amide.
It is important to know that the botanicals used are not useful for people with salicylate intolerance.
You probably already know that vitamin D is important for our bones and sufficient calcium absorption from the intestines. Less known is the particularly balancing role of vitamin D in the immune system: without sufficient vitamin D in the body, mast cells activate "automatically". Thus, vitamin D contributes to the normal functioning of the immune system.
Mast cells are white blood cells located in the tissues of our body. In the mast cells there are numerous small granules filled with messenger substances - e.g. histamine, heparin, prostaglandins etc.. When a mast cell is activated, the so-called degranulation occurs, which means that the stored messenger substances (approx. 200 different ones) are released.
Food supplements
Do not exceed the recommended daily intake. Food supplements are not a substitute for a balanced and varied diet.
Keep out of reach of children.
Storage
Store in a dry, cool place away from light. Keep away from heat and direct sunlight.
Packing
Packed in a light-protected PETPacker can - free of BPA.
What else can I do for a good immune system?
The basic prerequisite is, of course, that you give your body all the nutrients it needs - especially the proteins and essential amino acids as well as the anti-inflammatory omega-3 fatty acids (mainly found in fatty fish) are particularly important building blocks for many enzymes and new cells. So try to eat as balanced and varied a diet as possible - especially unprocessed foods, lots of vegetables, grains, nuts and seeds. This also supports the development of a healthy intestinal flora - and health often starts in the intestine!
Try to avoid alcohol as much as possible - it can have an immunosuppressive effect and changes your gut flora.
Often our immune system gets out of balance when our body is stressed - this can be a mental strain, physical overload or an infection. It is not always possible to quickly change this stress. Breathing exercises and yoga as well as endurance sports can help reduce the body's stress response. Regular breaks and downtime are just as important - try setting your mobile phone alarm every 1-2h, getting up from your desk and taking a few steps.
Many patients with mast cell activation syndrome can additionally pay attention to mast cell liberators in their diet. The following list gives you an overview:
Mast cell liberators_food list
Ingredients
| Ingredients per daily dose (4 capsules) |
|
%NRV* |
| Vitamin D |
1000 IU (25 ug) |
500* |
| Quercetin |
1000 mg |
-** |
| PEA (palmitoylethanolamide) |
900 mg |
-** |
| Luteolin |
50 mg |
-** |
| Rutin |
500mg |
-** |
| Genistein |
50 mg |
-** |
*Percentage of the nutrient reference quantity according to Regulation (EU) No. 1169/2011
**no reference available
Capsule shell: hydroxpropylmethylcellulose, guaranteed free from PEG and carrageenan
No fillers.
Allergens: none contained
Capsule weight: 769.4 mg
Net weight per can (120 capsules): 92.3 g
Recommended intake / dosage
Take 2 capsules with 200 ml of water twice daily with food or with a little oil.
For a lasting effect, we recommend taking it for at least 8 weeks.
Contraindications
In rare cases, flavonoids may cause nausea or constipation. PEA can have a vasodilatory effect.
It is not recommended to be taken in case of salicylate intolerance.
As there are no studies on use during pregnancy, breastfeeding or in children, we recommend taking it in these cases only after consulting a doctor.
Our quality promise
Our capsules are made of HPMC (hydroxypropylmethylcellulose) - i.e. vegetable cellulose and do not contain any potentially harmful substances such as PEG (polyethylene glycol) or carrageenan.
All ingredients are tested in an HACCP- and GMP-certified plant in Austria according to the quality standards valid in the EU and are also encapsulated here.
We do not use any potentially harmful release agents or superplasticisers such as titanium dioxide or silicon dioxide; if necessary, we use microcrystalline cellulose as a filler.
All our products are GMO-free, gluten-free and lactose-free. All products are also suitable for a vegan diet.
For all those who would like to know more:
Here you will find selected studies that have investigated a potential benefit of the substances used or simply explain the topic of immune system regulation and mast cells in more detail:
Quercetin:
Cheng SC, Huang WC, S Pang JH, Wu YH, Cheng CY. Quercetin Inhibits the Production of IL-1β-Induced Inflammatory Cytokines and Chemokines in ARPE-19 Cells via the MAPK and NF-κB Signaling Pathways. Int J Mol Sci. 2019 Jun 17;20(12):2957. doi: 10.3390/ijms20122957. PMID: 31212975; PMCID: PMC6628093.
Shaik Y, Caraffa A, Ronconi G, Lessiani G, Conti P. Impact of polyphenols on mast cells with special emphasis on the effect of quercetin and luteolin. Cent Eur J Immunol. 2018;43(4):476-481. doi: 10.5114/ceji.2018.81347. epub 2018 Dec 31. PMID: 30799996; PMCID: PMC6384425.
Palmitoylethanolamide:
Artukoglu BB, Beyer C, Zuloff-Shani A, Brener E, Bloch MH. Efficacy of Palmitoylethanolamide for Pain: A Meta-Analysis. Pain Physician. 2017 Jul;20(5):353-362. PMID: 28727699.
Skaper SD, Facci L, Giusti P. Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator. Mol Neurobiol. 2013 Oct;48(2):340-52. doi: 10.1007/s12035-013-8487-6. epub 2013 Jun 28. PMID: 23813098.
Vitamin D:
Liu ZQ, Li XX, Qiu SQ, Yu Y, Li MG, Yang LT, Li LJ, Wang S, Zheng PY, Liu ZG, Yang PC. Vitamin D contributes to mast cell stabilization. Allergy. 2017 Aug;72(8):1184-1192. doi: 10.1111/all.13110. epub 2017 Jan 17. PMID: 27998003.
Genistein:
Spagnuolo C, Russo GL, Orhan IE, Habtemariam S, Daglia M, Sureda A, Nabavi SF, Devi KP, Loizzo MR, Tundis R, Nabavi SM. Genistein and cancer: current status, challenges, and future directions. Adv Nutr. 2015 Jul 15;6(4):408-19. doi: 10.3945/an.114.008052. PMID: 26178025; PMCID: PMC4496735.
Luteolin:
Seelinger G, Merfort I, Schempp CM. Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. Planta Med. 2008 Nov;74(14):1667-77. doi: 10.1055/s-0028-1088314. epub 2008 Oct 20. PMID: 18937165.
Yu MS, Lee J, Lee JM, Kim Y, Chin YW, Jee JG, Keum YS, Jeong YJ Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13. Bioorg Med Chem Lett. 2012 Jun 15; 22(12):4049-54.
Weng Z, Patel AB, Panagiotidou S, Theoharides TC . The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. J Allergy Clin Immunol. 2015 Apr; 135(4):1044-1052.e5.
Mast cells:
Hagenlocher Y, Lorentz A. Immunomodulation of mast cells by nutrients. Mol Immunol. 2015 Jan; 63(1):25-31.
Alexandrakis M, Singh L, Boucher W, Letourneau R, Theofilopoulos P, Theoharides TC. Differential effect of flavonoids on inhibition of secretion and accumulation of secretory granules in rat basophilic leukemia cells. Int J Immunopharmacol. 1999 Jun; 21(6):379-90.
